Chronic Recurrent Multifocal Osteomyelitis (CRMO) affects predominantly children and adolescents, with a peak age of onset of 10 years and a female preponderance. CRMO is characterized by recurrent inflammation at multiple skeletal sites , most commonly involving the tibia, femur, clavicle, foot, or vertebral body and rarely the pelvis or rib cage. Associated inflammatory disorders , includes → Palmoplantar pustulosis → Chronic arthritis → Psoriasis → Inflammatory bowel disease → Pyoderma gangrenosum → Sweet's syndrome, and → Severe acne. Clinical Features → Multiple episodes of localized redness, pain, & swelling of insidious onset & spontaneous regression . → Minimal functional impairment during the episodes. Pathophysiology The pathogenesis of this condition remains unexplained. Theories include an autoimmune process or an infecti