· Bone remodeling is a lifelong process wherein old bone is removed from the skeleton (a sub- process called bone resorption), and new bone is added (a sub-process called ossification or bone formation). · Remodelling involves continuous removal of discrete packets of old bone, replacement of these packets with newly synthesized proteinaceous matrix, and subsequent mineralization of the matrix to form new bone. · These processes also control the reshaping or replacement of bone during growth and following injuries like fractures but also microdamage. · Remodelling responds also to functional demands of the mechanical loading. · As a result, bone is added where needed and removed where it is not required. · This process is essential in the maintenance of bone strength and mineral homeostasis. · The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. · ...