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Bone Modelling And Remodelling

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·   Bone remodeling is a lifelong process wherein old bone is removed from the skeleton (a sub- process called bone resorption), and new bone is added (a sub-process called ossification or bone formation). ·    Remodelling involves continuous removal of discrete packets of old bone, replacement of these packets with newly synthesized proteinaceous matrix, and subsequent mineralization of the matrix to form new bone. ·   These processes also control the reshaping or replacement of bone during growth and following injuries like fractures but also microdamage. ·     Remodelling responds also to functional demands of the mechanical loading. ·    As a result, bone is added where needed and removed where it is not required. ·    This process is essential in the maintenance of bone strength and mineral homeostasis. ·   The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. · ...

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